Towards Autonomic Service Provisioning Systems

This paper discusses our experience in building SPIRE, an autonomic system for service provision. The architecture consists of a set of hosted Web Services subject to QoS constraints, and a certain number of servers used to run session-based traffic. Customers pay for having their jobs run, but require in turn certain quality guarantees: there are different SLAs specifying charges for running jobs and penalties for failing to meet promised performance metrics. The system is driven by an utility function, aiming at optimizing the average earned revenue per unit time. Demand and performance statistics are collected, while traffic parameters are estimated in order to make dynamic decisions concerning server allocation and admission control. Different utility functions are introduced and a number of experiments aiming at testing their performance are discussed. Results show that revenues can be dramatically improved by imposing suitable conditions for accepting incoming traffic; the proposed system performs well under different traffic settings, and it successfully adapts to changes in the operating environment.Comment: 11 pages, 9 Figures, http://www.wipo.int/pctdb/en/wo.jsp?WO=201002636

Revenue maximization problems in commercial data centers

PhD ThesisAs IT systems are becoming more important everyday, one of the main concerns is that users may face major problems and eventually incur major costs if computing systems do not meet the expected performance requirements: customers expect reliability and performance guarantees, while underperforming systems loose revenues. Even with the adoption of data centers as the hub of IT organizations and provider of business efficiencies the problems are not over because it is extremely difficult for service providers to meet the promised performance guarantees in the face of unpredictable demand. One possible approach is the adoption of Service Level Agreements (SLAs), contracts that specify a level of performance that must be met and compensations in case of failure. In this thesis I will address some of the performance problems arising when IT companies sell the service of running ‘jobs’ subject to Quality of Service (QoS) constraints. In particular, the aim is to improve the efficiency of service provisioning systems by allowing them to adapt to changing demand conditions. First, I will define the problem in terms of an utility function to maximize. Two different models are analyzed, one for single jobs and the other useful to deal with session-based traffic. Then, I will introduce an autonomic model for service provision. The architecture consists of a set of hosted applications that share a certain number of servers. The system collects demand and performance statistics and estimates traffic parameters. These estimates are used by management policies which implement dynamic resource allocation and admission algorithms. Results from a number of experiments show that the performance of these heuristics is close to optimal.QoSP (Quality of Service Provisioning)British Teleco

On Allocation Policies for Power and Performance

With the increasing popularity of Internet-based services and applications, power efficiency is becoming a major concern for data center operators, as high electricity consumption not only increases greenhouse gas emissions, but also increases the cost of running the server farm itself. In this paper we address the problem of maximizing the revenue of a service provider by means of dynamic allocation policies that run the minimum amount of servers necessary to meet user's requirements in terms of performance. The results of several experiments executed using Wikipedia traces are described, showing that the proposed schemes work well, even if the workload is non-stationary. Since any resource allocation policy requires the use of forecasting mechanisms, various schemes allowing compensating errors in the load forecasts are presented and evaluated.Comment: 8 pages, 11 figures, 2010 11th IEEE/ACM International Conference on Grid Computing (GRID), pp 313 - 320 (E2GC2-2010 workshop

Revenue maximization problems in commercial data centers

As IT systems are becoming more important everyday, one of the main concerns is that users may face major problems and eventually incur major costs if computing systems do not meet the expected performance requirements: customers expect reliability and performance guarantees, while underperforming systems loose revenues. Even with the adoption of data centers as the hub of IT organizations and provider of business efficiencies the problems are not over because it is extremely difficult for service providers to meet the promised performance guarantees in the face of unpredictable demand. One possible approach is the adoption of Service Level Agreements (SLAs), contracts that specify a level of performance that must be met and compensations in case of failure. In this thesis I will address some of the performance problems arising when IT companies sell the service of running ‘jobs’ subject to Quality of Service (QoS) constraints. In particular, the aim is to improve the efficiency of service provisioning systems by allowing them to adapt to changing demand conditions. First, I will define the problem in terms of an utility function to maximize. Two different models are analyzed, one for single jobs and the other useful to deal with session-based traffic. Then, I will introduce an autonomic model for service provision. The architecture consists of a set of hosted applications that share a certain number of servers. The system collects demand and performance statistics and estimates traffic parameters. These estimates are used by management policies which implement dynamic resource allocation and admission algorithms. Results from a number of experiments show that the performance of these heuristics is close to optimal.EThOS - Electronic Theses Online ServiceQoSP (Quality of Service Provisioning) : British TelecomGBUnited Kingdo

Study of Realistic Antenna Patterns in 5G mmWave Cellular Scenarios

Large antenna arrays and millimeter-wave (mmWave) frequencies have been attracting growing attention as possible candidates to meet the high requirements of future 5G mobile networks. In view of the large path loss attenuation in these bands, beamforming techniques that create a beam in the direction of the user equipment are essential to perform the transmission. For this purpose, in this paper, we aim at characterizing realistic antenna radiation patterns, motivated by the need to properly capture mmWave propagation behaviors and understand the achievable performance in 5G cellular scenarios. In particular, we highlight how the performance changes with the radiation pattern used. Consequently, we conclude that it is crucial to use an accurate and realistic radiation model for proper performance assessment and system dimensioning.Comment: to be published in 2018 IEEE ICC Communications QoS, Reliability, and Modeling Symposium (ICC18 CQRM), Kansas City, USA, May 201

Correction: Unexpected optical activity of cerium in Y2O3:Ce3+, Yb3+, Er3+ up and down-conversion system

Correction for 'Unexpected optical activity of cerium in Y2O3:Ce3+, Yb3+, Er3+ up and down-conversion system' by Riccardo Marin et al., Dalton Trans., 2013, 42, 16837–16845

Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries

<p>Abstract</p> <p>Background</p> <p>Atherosclerosis affects aorta, coronary, carotid, and iliac arteries most frequently than any other body vessel. There may be common molecular pathways sustaining this process. Plaque presence and diffusion is revealed by circulating factors that can mediate systemic reaction leading to plaque rupture and thrombosis.</p> <p>Results</p> <p>We used DNA microarrays and meta-analysis to study how the presence of calcified plaque modifies human coronary and carotid gene expression. We identified a series of potential human atherogenic genes that are integrated in functional networks involved in atherosclerosis. Caveolae and JAK/STAT pathways, and S100A9/S100A8 interacting proteins are certainly involved in the development of vascular disease. We found that the system of caveolae is directly connected with genes that respond to hormone receptors, and indirectly with the apoptosis pathway.</p> <p>Cytokines, chemokines and growth factors released in the blood flux were investigated in parallel. High levels of RANTES, IL-1ra, MIP-1alpha, MIP-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-17, PDGF-BB, VEGF and IFN-gamma were found in plasma of atherosclerotic patients and might also be integrated in the molecular networks underlying atherosclerotic modifications of these vessels.</p> <p>Conclusion</p> <p>The pattern of cytokine and S100A9/S100A8 up-regulation characterizes atherosclerosis as a proinflammatory disorder. Activation of the JAK/STAT pathway is confirmed by the up-regulation of IL-6, STAT1, ISGF3G and IL10RA genes in coronary and carotid plaques. The functional network constructed in our research is an evidence of the central role of STAT protein and the caveolae system to contribute to preserve the plaque. Moreover, Cav-1 is involved in SMC differentiation and dyslipidemia confirming the importance of lipid homeostasis in the atherosclerotic phenotype.</p

Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990–2015)

Objective: In many Western countries, survival from vulvar squamous cell carcinoma (VSCC) has been stagnating for decades or has increased insufficiently from a clinical perspective. In Italy, previous studies on cancer survival have not taken vulvar cancer into consideration or have pooled patients with vulvar and vaginal cancer. To bridge this knowledge gap, we report the trend in survival from vulvar cancer between 1990 and 2015. (2) Methods: Thirty-eight local cancer registries covering 49% of the national female population contributed the records of 6274 patients. Study endpoints included 1- and 2-year net survival (NS) calculated using the Pohar-Perme estimator and 5-year NS conditional on having survived two years (5|2-year CNS). The significance of survival trends was assessed with the Wald test on the coefficient of the period of diagnosis, entered as a continuous regressor in a Poisson regression model. (3) Results: The median patient age was stable at 76 years. One-year NS decreased from 83.9% in 1990–2001 to 81.9% in 2009–2015 and 2-year NS from 72.2% to 70.5%. Five|2-year CNS increased from 85.7% to 86.7%. These trends were not significant. In the age stratum 70–79 years, a weakly significant decrease in 2-year NS from 71.4% to 65.7% occurred. Multivariate analysis adjusting for age group at diagnosis and geographic area showed an excess risk of death at 5|2-years, of borderline significance, in 2003–2015 versus 1990–2002. (4) Conclusions: One- and 2-year NS and 5|2-year CNS showed no improvements. Current strategies for VSCC control need to be revised both in Italy and at the global level